VNS Therapy (or the VNS Therapy System) is indicated for the adjunctive long-term treatment of chronic or recurrent depression for patients over the age of 18 who are experiencing a major depressive episode and have not had an adequate response to four or more adequate antidepressant treatments.1
Learn more about patients who received VNS Therapy in clinical studies.
Click here for a checklist that will help determine if VNS Therapy is right for your patients.
Hear from a physician
"I would consider VNS Therapy under two different but related circumstances. First, for individuals who have had several different individual treatment trials, different medications or combinations. Perhaps three or four, or even more, of those kinds of treatments and the individual has not had an adequate acute response, that is they have not gotten rid of their symptoms adequately. So those individuals would clearly be candidates for VNS Therapy.
"In those individuals who had a good initial response but are unable to sustain it over time, even though they are taking the treatments, they are also good candidates for VNS Therapy."
—Dr. A. John Rush, Vice Chair, Department of Clinical Sciences Professor, Department of Psychiatry University of Texas Southwestern Medical Center at Dallas
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TRD Outcomes is an effectiveness assessment database designed to collect outcomes and summarize aggregate results of early post-approval experience with VNS Therapy in TRD. TRD Outcomes will provide “real world” insight and experience to assist you and your patients in making treatment decisions. Learn more about the TRD Outcomes project by clicking here.
The safety and efficacy of this therapy have not been systematically established in patients with the following conditions: depression with a history of schizophrenia, schizoaffective disorder, or delusional disorders, depression with a history of rapid cycling bipolar disorder, cardiac arrhythmias or other abnormalities, history of dysautonomias, history of previous therapeutic brain surgery, history of respiratory diseases or disorders, including dyspnea and asthma, history of ulcers (gastric, duodenal, or other), history of vasovagal syncope, neurological diseases other than epilepsy or depression, only one vagus nerve, other concurrent forms of brain stimulation, pre-existing hoarseness, pregnancy or nursing.1
1. Depression Physician's Manual. VNS Therapy Pulse Model 102 Generator and VNS Therapy Pulse Duo Model Generator. Houston, Tex: Cyberonics, Inc; 2005.