Further Reading and LInks

D-21 Clinical Study
Cyberonics is currently sponsoring a post market clinical study on VNS Therapy in patients with Treatment Resistant Depression. This study is currently enrolling participants. To learn more about this study, please go to the following website: http://clinicaltrials.gov/ct/show/NCT00305565?order=1

Depression and Bipolar Support Alliance
The Depression and Bipolar Support Alliance (DBSA) is the nation's leading patient-directed mental health organization. It focuses on depression and bipolar disorder, with links to local support groups nationwide.

American Psychiatric Association
Find news, research and clinical resources, education, and guidelines from the nation's oldest national medical specialty society. The information you can access here includes many FAQs on illnesses and on choosing a psychiatrist.

The National Institute of Mental Health (NIMH) Web site provides information from the federal agency that conducts and supports research on mental illnesses. It focuses on accelerating discoveries in biomedical research on mind, brain, and behavior.

Mental Health America
Mental Health America (formerly known as the National Mental Health Association) is the country's largest nonprofit organization addressing all aspects of mental health and mental illness. With more than 320 affiliates nationwide, MHA works to improve the mental health of all Americans, especially the 54 million people with mental disorders, through advocacy, education, research and service.

Comprehensive health resource for consumers, physicians, nurses, and educators offers news, chat forums, health quizzes, and consumer product updates.

NAMI (the National Alliance on Mental Illness) is the nation’s largest grassroots mental health organization dedicated to improving the lives of persons living with serious mental illness and their families. NAMI is dedicated to the eradication of mental illnesses and to the improvement of the quality of life of all whose lives are affected by these diseases.

The following links are to websites developed by people who have experienced VNS Therapy for treatment-resistant depression:

This website is focused on educating patients about new FDA approved treatments for chronic depression and highlights one person's experience with VNS Therapy. In addition, this website features the recently published book, Out of the Black Hole: The Patient’s Guide to Vagus Nerve Stimulation and Depression.

This website was created by a spouse of a person with VNS Therapy to create an opportunity for education and to provide a forum for exchanging of experiences regarding VNS Therapy for treatment-resistant depression.


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The VNS Therapy System is indicated for use as an adjunctive therapy in reducing the frequency of seizures in adults and adolescents over 12 years of age with partial onset seizures, which are refractory to antiepileptic medications.

VNS Therapy (or the VNS Therapy System) is indicated for the adjunctive long-term treatment of chronic or recurrent depression for patients over the age of 18 who are experiencing a major depressive episode and have not had an adequate response to four or more adequate antidepressant treatments.